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Pretreatment with diosmin mitigated the altered serum levels of BUN (A), creatinine (B), and albumin (C) resulting from Dox treatment. Data are presented as the mean ± SD (n = 5) where ***p < 0.001, **p < 0.0, *p < 0.05, and NSp> 0.05. [CON, control; DOX, doxorubicin; DOX + DS100, doxorubicin plus diosmin 100 mg/kg; and DOX + DS200, doxorubicin plus diosmin 200 mg/kg, n = number of animals].
