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. 2021 Apr 17;28(8):4375–4383. doi: 10.1016/j.sjbs.2021.04.030

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© 2021 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Diosmin reduces oxidative stress and inflammatory protein expression and induces antioxidant proteins. (A & B) Immunoblot representation of SOD, IL-10, IL-6, NfkB-p65, TNF-α, Nox-4, and iNOS. (C–I) Graphical representation of SOD, IL-10, IL-6, NfkB-p65, TNF-α, Nox-4, and iNOS. Results are shown as the mean ± SD (n = 5) where ^***P < 0.001, ^**P < 0.01, *P < 0.05, and ^NSP > 0.05. [CON, control; DOX, doxorubicin; DOX + DS100, doxorubicin plus diosmin 100 mg/kg; and DOX + DS200, doxorubicin plus diosmin 200 mg/kg, n = number of animals].

Fig. 5 — Diosmin reduces oxidative stress and inflammatory protein expression and induces antioxidant proteins. (A & B) Immunoblot representation of SOD, IL-10, IL-6, NfkB-p65, TNF-α, Nox-4, and iNOS. (C–I) Graphical representation of SOD, IL-10, IL-6, NfkB-p65, TNF-α, Nox-4, and iNOS. Results are shown as the mean ± SD (n = 5) where ^***P < 0.001, ^**P < 0.01, *P < 0.05, and ^NSP > 0.05. [CON, control; DOX, doxorubicin; DOX + DS100, doxorubicin plus diosmin 100 mg/kg; and DOX + DS200, doxorubicin plus diosmin 200 mg/kg, n = number of animals].