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. 2021 Jul 26;16:5065–5098. doi: 10.2147/IJN.S321343

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© 2021 Allemailem et al.

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The inhibition of PPT1 by DQ661 and the regulation of multiple lysosome-facilitated signaling processes. The left half of the lysosome median line indicates the basal (control) conditions in absence of DQ661. The right side of the lysosome median line shows the effect of DQ661 binding to PPT1 directly within the lysosomal lumen, resulting in decreased macropinocytosis, autophagic flux, proliferation, and decreased tumor growth and enhanced apoptosis.