Table 3.

Examples of Different Drugs and Other Compounds Which Modulate the Iron Metabolism Mediated Ferroptosis with Different Types of Mechanisms

Drugs	Induction/Inhibition of Ferroptosis and the Mechanism of Action on Target in Different Cancer Types	References
Artesunate	Induction of iron metabolism on ferritinophagy as studied in cervical adenocarcinoma; and hepatocellular carcinoma	[165]
	Induction of iron metabolism on ferritinophagy, as studied in pancreatic cancer	[166]
	Inhibition of lipid peroxidation on NRF2, as studied in Head and neck cancer	[167]
Cisplatin	Induction of iron metabolism on ferritinophagy, as studied in lung cancer	[132]
	Induction of lipid peroxidation and Iron metabolism on GSH-GPXs and IREB2, as studied in colorectal cancer; NSCLC	[128]
Dihydroartemisinin	Induction of iron metabolism on ferritinophagy, as studied in lung cancer and colorectal cancer	[168]
	Induction of iron metabolism on ferritinophagy, as studied in head and neck cancer	[169]
	Induction of iron metabolism on ferritinophagy, as studied in acute myeloid leukemia	[170]
Gemcitabine	Inhibition of lipid peroxidation on GPX4, as studied in pancreatic cancer	[171]
Paclitaxel	Unknown effect of lipid peroxidation on P53:SLC7A11, as studied in colorectal carcinoma	[172]
	Unknown effect of lipid peroxidation on P53, as studied in lung cancer	[173]
Sulfasalazine	Induction of lipid peroxidation on SLC7A11, as studied in sarcoma and colorectal cancer	[174]
	Induction of lipid peroxidation on SLC7A11, as studied in glioma	[175]
Sorafenib	Induction of lipid peroxidation and Iron metabolism on NRF2, SLC7A11, and FTH, as studied in hepatocellular carcinoma	[176]
	Induction of lipid peroxidation on system Xc, as studied in sarcoma	[177]
	Induction of lipid peroxidation on SLC7A11, as studied in sarcoma and colorectal cancer	[174]
	Induction of lipid peroxidation on SLC7A11, as studied in glioma	[175]
Temozolomide	Inhibit of lipid peroxidation on SLC7A11 and transsulfuration pathway, as studied in glioblastoma multiforme	[178]