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. 2021 Jul 15;14(7):dmm048223. doi: 10.1242/dmm.048223

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 2. — Derived EMM cell line generated plasmocytomas when re-implanted in NSG mice. (A) Representative image of a plasmocytoma derived from EMM cell line by intradermal injection of 1×10⁶ cells soaked in Matrigel in the flank of an NSG mouse. (B) Tumor growth rate of plasmocytomas generated after the intradermic injection of 1×10⁶ cells of the EMM cell line (n=6). (C) Tumors reached a mean volume of 280±34 mm³ at 30 days post-injection. (D) H&E staining of the cell line-derived plasmocytomas showing histological similarities with the PDOX and the patient's biopsy (at 400× magnification). (E) Cell line-derived plasmocytomas showed a high Ki67 expression as observed in the EMM PDOX (at 400× magnification). Data are mean±s.e.m.