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. 2021 Jul 15;14(7):dmm048223. doi: 10.1242/dmm.048223

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© 2021. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Cytogenetic abnormalities observed in EMM PDOX. (A) Diagram representing the cytogenetic abnormalities observed in EMM PDOX by single-nucleotide polymorphism genotyping microarray performed using a CytoScan 750 K Array. CNAs are extensively distributed along all chromosomes and included gains, losses and LOH. (B,C) Presence of extensive intrachromosomal CNAs. Details of CNA analysis of the short arm of chromosome 7 (B) showing a highly disturbed genome with gains of up to 28 copies concomitant with extensive genetic losses and LOH and detail of CNA in the short arm of chromosome 19 (C) showing a gain region of 12.8 mb with seven copies.