Table 6.
Multivariate Analysis for OS and DFS in AML Patients
| Covariates | OS | DFS | |||||
|---|---|---|---|---|---|---|---|
| P | HR | 95% CI | P | HR | 95% CI | ||
| Age (years) | 0.043 | 1.032 | 1.001-1.065 | 0.245 | 0.832 | 0.609-1.135 | |
| Marrow blast (%) | 0.052 | 1.027 | 0.998-1.054 | 0.585 | 1.021 | 0.948-1.099 | |
| Combined CXCR4 expression & SDF-1 polymorphism | CXCR4negative and SDF-1 GG | - | 1 | Reference | - | 1 | Reference |
| CXCR4negative and SDF-1 AG+AA | 0.071 | 2.712 | 0.917-8.026 | 0.132 | 2.877 | 0.202-2.119 | |
| CXCR4positive and SDF-1 AA | 0.111 | 2.587 | 0.804-8.326 | 0.18 | 1.703 | 0.055-5.226 | |
| CXCR4positive and SDF-1 AG+AA | 0.031 | 4.274 | 1.161-15.738 | 0.872 | 0.575 | 0.001-4.133 | |
| Cytogenetic risk stratification | Favorable | - | 1 | Reference | - | 1 | Reference |
| Intermediate | 0.003 | 3.701 | 1.544-8.871 | 0.135 | 0.956 | 0.784-1.125 | |
| Unfavorable | 0.001 | 4.165 | 1.840-9.427 | 0.834 | 0.849 | 0.183-3.937 | |
CI 95%, Confidence interval at 95%; OS, Overall survival; DFS, Disease free survival; HR, High risk.