Table 1.

Age- and CAG-dependent changes of mtDNA heteroplasmies in lymphoblasts of HD patients

Variables	mtDNA variant pathogenicity	Age		CAG repeat length		Age × CAG repeat length
		Beta (SE)	P	Beta (SE)	P	Beta (SE)	P
mtDNA variant dosages	M/H	0.012 (0.003)	0.00011	0.018 (0.012)	0.15	0.0014 (0.0006)	0.011
	H	0.012 (0.003)	5.8 × 10−5	0.025 (0.012)	0.035	0.0015 (0.0005)	0.0062
	others	0.013 (0.003)	7.4 × 10−5	0.003 (0.013)	0.82	0.0003 (0.0006)	0.55
mtDNA variant incidence	M/H	0.009 (0.003)	0.0046	0.014 (0.012)	0.26	0.0014 (0.0005)	0.013
	H	0.010 (0.003)	0.00065	0.024 (0.012)	0.040	0.0013 (0.0005)	0.014
	others	0.015 (0.003)	4.8 × 10−6	0.002 (0.013)	0.87	0.0007 (0.0006)	0.23

The variant incidence and dosages of mtDNA heteroplasmies were inverse normal transformed (INV) and were further adjusted for sex and sequencing coverage. The values of age and CAG repeat length were centered at the population mean. The associations were assessed by using the model: INV dosage/incidence ∼ age + CAG_length + age × CAG_length. H, high pathogenicity; M/H, medium or high pathogenicity; others, not predicted with medium or high pathogenicity. Values of P < 0.05 are highlighted in bold type.