Fig. 1.

A pyramidal cell model with active dendrites reproduces dendritic responses to visual stimulation in vivo. (A) Morphology of the L2/3 pyramidal neuron used for the model, with pipettes indicating the locations of the recordings shown in B. (B) Example of somatic (Left) and dendritic (light blue, Right) responses of the postsynaptic model neuron to simulated synaptic inputs corresponding to visual stimuli with orientations 0°, 45°, 90°, and 135°, where 90° is the preferred orientation of the model neuron. (C) Comparison of dendritic patch-clamp recordings in vivo [pink, Left; data from Smith et al. (17)] with dendritic recordings in the model neuron (light blue, Right). Note that vertical scale bars differ between traces. (D) Comparison of event rates in the experiment [pink; using data from Smith et al. (17)] and model (light blue). Events are defined as episodes of monotonically rising membrane potential with a baseline-to-peak difference of more than 10 mV.