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A-to-I and C-to-U off-target events of RESCUE and ecDHFR DD-fused RESCUE RNA editors. a Schematic of KRAS, NFKB1, and NRAS target sites and guide RNA design. Manhattan plots showing the distribution of modified b adenines and c cytosines across the transcriptome for KRAS, NFKB1, and NRAS RNA A-to-I and C-to-U editing, respectively, by RESCUE and ecRESCUE editors (n = 2 for each system; coverage: × 50). n, total number of modified adenines identified
