. 2021 Jul 31;21:448. doi: 10.1186/s12877-021-02387-4

Table 3.

Associate between the Framingham Risk Score (FRS) at baseline (wave 1) and incident frailty during the follow-up (wave2-wave3)

	Model 1 ^a		Model 2 ^b		Model 3 ^c
	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
Generalized FRS [2008](n=2,901)	1.03 (1.01 to 1.06)	0.013	1.03 (1.00 to 1.06)	0.030	1.00 (0.97 to 1.03)	0.773
Generalized FRS [2008] after excluding incident CVD (n=2,669)	1.03 (1.01 to 1.06)	0.017	1.03 (1.00 to 1.06)	0.049	0.99 (0.96 to 1.03)	0.651
Generalized FRS [2008] after excluding baseline depression (n=2,311)	1.05 (1.01 to 1.08)	0.005	1.05 (1.01 to 1.08)	0.010	1.01 (0.97 to 1.05)	0.668
Updated FRS [2015]^d (n=2,901)	1.10 (1.05 to 1.16)	<0.001	1.08 (1.02 to 1.14)	0.009	0.99 (0.93 to 1.07)	0.865

^aAdjusted for sex

^bAdjusted for sex, education, marital status, obesity, comorbidity burden, cognitive function

^cAdjusted for sex, age, education, marital status, obesity, comorbidity burden, cognitive function