. 2021 Jul 31;21:448. doi: 10.1186/s12877-021-02387-4

Table 4.

Associate between FRS at baseline (wave 1) and combined mortality and incident frailty during the follow-up (wave2-wave3)

	Model 1 ^a		Model 2 ^b		Model 3 ^c
	HR (95% CI)	p Value	HR (95% CI)	p Value	HR (95% CI)	p Value
Generalized FRS [2008] (n=3,033)	1.06 (1.04 to 1.09)	<0.001	1.05 (1.02 to 1.08)	<0.001	1.02 (0.99 to 1.05)	0.327
Generalized FRS [2008] after excluding incident CVD (n=2,794)	1.06 (1.03 to 1.09)	<0.001	1.05 (1.02 to 1.09)	<0.001	1.01 (0.98 to 1.05)	0.381
Generalized FRS [2008] after excluding baseline depression (n=2,407)	1.08 (1.04 to 1.11)	<0.001	1.07 (1.03 to 1.11)	<0.001	1.03 (1.00 to 1.07)	0.078
Updated FRS [2015]^d (n=3,033)	1.16 (1.11 to 1.21)	<0.001	1.13 (1.08 to 1.19)	<0.001	1.04 (0.98 to 1.10)	0.198

^aAdjusted for sex

^bAdjusted for sex, education, marital status, obesity, comorbidity burden, cognitive function score

^cAdjusted for sex, age, education, marital status, obesity, comorbidity burden, cognitive function score