Table 2.
Monoclonal antibodies in clinical trials for the treatment of head and neck cancers
| mAb | Target | Phase | Combined with | ClinicalTrials.gov Identifier |
|---|---|---|---|---|
| Bevacizumab | VEGF-A | III | Chemotherapy | NCT00588770 |
| Bevacizumab | VEGF-A | I/II | Erlotinib | NCT00055913 |
| Ramucirumab | VEGFR2 | I/II | Pembrolizumab | NCT03650764 |
| Ficlatuzumab | HGF | II | Cetuximab | NCT03422536 |
| Cetuximab | EGFR | II | – | NCT03769311 |
| Cetuximab | EGFR | II | Afatinib | NCT02979977 |
| Trastuzumab | HER2 | II | – | NCT00004163 |
| Panitumumab | EGFR | II | Paclitaxel | NCT01264328 |
| Panitumumab | EGFR | I | Chemotherapy | NCT00513383 |
| Nivolumab | PD-1 | II | Paclitaxel | NCT04282109 |
| Nivolumab | PD-1 | II | Relatlimab/Ipilimumab | NCT04080804 |
| Pembrolizumab | PD-1 | I | Clopidogrel/Acetylsalicylic acid | NCT03245489 |
| Pembrolizumab | PD-1 | II | Tadalafil | NCT03993353 |
| Atezolizumab | PD-L1 | II | Bevacizumab | NCT03818061 |
| Durvalumab | PD-L1 | II | Cetuximab | NCT03691714 |
| Durvalumab | PD-L1 | II | Carboplatin/Paclitaxel | NCT03723967 |
| Ipilimumab | CTLA-4 | I | – | NCT02812524 |
| Tremelimumab | CTLA-4 | II | Durvalumab/Radiotherapy | NCT03624231 |