Fig. 1.
AAN-II facilitates ulcer healing by suppressing the development of inflammation in pressure-induced venous ulcers in a rabbit model. A Gross observation was performed to determine the pathological skin changes in the three groups. Representative images are shown (n = 10). B The ulcer area (cm2) was calculated on days 7 and 14 and the values are expressed as means ± SEM. *p < 0.05 compared with the control group. #p < 0.05 compared with the ulcer group. C Percentage of ulcer healing was calculated on days 7 and 14 and the values are expressed as means ± SEM. *p < 0.05 compared with the control group. #p < 0.05 compared with the ulcer group. D through G The levels of IL-1β (D), IL-6 (E), TNF-α (F) and IL-4 (G) were determined using ELISA kits. Values are expressed as means ± SEM. *p < 0.05 compared with the control group. #p < 0.05 compared with the ulcer group