Table 1.

Start and end dates of study period at each site for validation cohort creation

Site	Start and End Dates
Alberta	June 6, 2014 – December 31, 2016
British Columbia	June 3, 2014 – June 30, 2018
Manitoba	June 9, 2014 – December 31, 2017
Ontario	July 29, 2015 – December 31, 2016
Quebec	September 4, 2014 – December 31, 2016
Clinical Practice Research Datalink	February 4, 2013 – December 31, 2017

Note: Study period is limited to the years for which both vital statistics registrations and administrative health records were available at each site