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. 2021 Jul 31;19:325. doi: 10.1186/s12967-021-03012-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Risk model for disease-free survival. A Coefficients of the risk sore model by multivariate COX regression and the ligands in the model. B Risk score and expression of AREG, EFNA5, COL1OA1, TGFB2 and VEGFB for each individual in TCGA cohort. C ROC curve of predicted survival at 1 year, 2 year and 5 year time point. D Kaplan–Meier plot of low and high risk group