Table 5.

FISH, AB type, FCM and chromosomal karyotyping of BAL with KMT2Ar according to the literature review

Pt	KMT2A-FISH	MYC-FISH	Transcripta	Protocol	Treatment response	HSCT	Relapse	EFS (m)
1	ND	ND	ND	VLP	Refractory	Refractory	Refractory	9 (OS)
2	Pos	ND	KMT2A +	LMB89	CR	0	BM, CNS	9
3	Neg	Neg	ND	COG-ALL-1961	CR	No	No	9
4	Pos	Neg	ND	CCG-ALL-1991	CR	No	No	4
5	Pos	Neg	ND	Infant ALL	CR	No	No	4
6	Pos	Neg	ND	Interfant-99	CR	No	BM, TL	4
7	Pos	Neg	ND	Interfant-99	CR	4/6 matched CBT	BM	6
8	Pos	Neg	ND	LMB89 trial	CR	No	BM, CNS	6
9	ND	Neg	ND	EORTC 02	CR	No	BM, CNS	6
10	Pos	Neg	KMT2A-MLLT10	Interfant-99	CR	No	No	24
11	Pos	Neg	ND	FRALLE 2000	CR	No	No	35
12	Pos	Neg	ND	Interfant-99	CR	No	TL	14
13	Pos	ND	ND	ALL like	Died	died	died	1.25 (OS)
14	Pos	Neg	KMT2A-MLLT3	ALL	CR	No	No	8
15	Neg	Neg	Neg	ALL	CR	No	No	48
16	Pos	ND	KMT2A/MLLT5	Interfant-99	CR	No	BM, TL	4
17	Pos	ND	KMT2A-MLLT1	BFM-2004	CR	No	BM, TL	19
18	Pos	ND	KMT2A-MLLT1	Interfant-99	CR	No	BM	21
19	Pos	ND	KMT2A-MLLT10	Interfant-99	CR	No	No	32
20	Pos	ND	KMT2A-MLLT5	ALLIC-09	CR	No	No	21
21	Pos	ND	KMT2A-MLLT3	BFM like	CR	Sible-HSCT	No	108
22	Pos	Neg	KMT2A-MLLT3	KMT2A03	CR	mismatched-CBT	No	72
23	ND	ND	KMT2A-MLLT3	BFM-95	CR	MUD-CBT	No	12
24	ND	Neg	KMT2A-MLLT3	B-NHL-2010	CR	No	CNS	13

ND, no data; Pos, positive; Neg: negative; HSCT, haematopoietic stem cell transplantation; CBT, cord blood transplant; MUD, matched unrelated donor; BM, bone marrow; TL, testicular leukaemia; CNS, central nervous system; EFS, event-free survival; OS, overall survival

^aTranscripts of KMT2Ar were detected by RT-PCR except for patient 2, who was tested by Northern Blot