Fig. 2.

Chronotype score in GEP-NET patients according to the clinical pathological characteristics. Metastatic stage, grading G2 and progressive disease presented the lower chronotype score (p = 0.004, p < 0.001, and p = 0.002; respectively) compared to other categories of the clinical pathological characteristics. Differences in metastasis and grading were analysed by paired Student’s t test, while ANOVA test, with the Bonferroni test as post-hoc test was used to evaluate differences in progressive disease. *A p value in bold type denotes a significant difference (p < 0.05). G, grading