ACE2 (blue) residues Gln24, Asp30, His34, Tyr41, Gln42, Met82, Asp330, Lys353, and Asp355 (green). A) ACE2 with 18 conformers of the ED compound (pink), B) ACE2 interacting with RBD of the S-protein (red) and the amino acid in position 501 (Asn, Cyan).