Figure 3. Effect of cutaneous Lewisite exposure on cytokines and IPA analysis for altered disease and cellular pathways.
Animals were exposed to indicated doses of Lewisite. (A) A panel of cytokines was evaluated in the lung tissue lysates using a bead-based Luminex multiplex immunoassay system and only the significantly altered cytokines are shown. This data was further analyzed by Ingenuity Pathway Analysis (IPA) and the predicted effects of altered cytokines on (B) immunological/inflammatory and (C) cellular and disease processes are shown.