Table 1. Main Treatments of Narcolepsy .

EDS: excessive daytime sleepiness

Drugs	Dosage	Indication	Mechanism of action
Modafinil	100 - 400 mg	First-line treatment for EDS	Promotes wakefulness by stimulating histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems in the brain [12].
Solriamfetol	75 - 150 mg	First-line treatment for EDS	Possible increased activity as a dopamine and norepinephrine reuptake inhibitor [13].
Pitolisant	4.5 - 36.0 mg	First-line treatment for EDS and cataplexy	H3 receptor antagonist/inverse agonist [2].
Methylphenidate	10 - 60 mg	Second-line treatment for EDS	Non-competitively blocks the reuptake of dopamine and noradrenaline into the terminal by blocking dopamine transporter (DAT) and noradrenaline transporter (NAT), increasing levels of dopamine and noradrenaline in the synaptic cleft [14].
Amphetamines	Amphetamine mixed salts: 10 - 60 mg; Dexamphetamine: 10 - 60 mg	Second-line treatment for EDS	Elevates extracellular dopamine (DA) and prolonging DA receptor signaling in the striatum [15].