Table 2.
Unadjusted and adjusted regression model for in-hospital death or discharge to hospice
| Unadjusted regression model | Adjusted regression modela | |||
|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | |
| COVID-19 admission | 0.88 (0.47–1.64) | 0.68 | ||
| Door-to-needle, per hour | 1.08 (1.01–1.17) | 0.03 | 1.15 (1.07–1.24) | < 0.001 |
| Door-to-needle × COVID-19 period | 0.97 (0.83–1.13) | 0.65 | ||
| Age, per decade | 1.72 (1.39–2.12) | < 0.001 | 1.35 (1.11–1.64) | < 0.001 |
| Female sex | 1.36 (0.80–2.29) | 0.25 | ||
| White race | 2.20 (1.06–4.56) | 0.03 | 2.09 (0.98–4.45) | 0.056 |
| Hispanic ethnicity | 0.97 (0.56–1.70) | 0.92 | ||
| Transfer from outside hospital | 1.14 (0.26–5.03) | 0.87 | ||
| Hypertension | 1.07 (0.58–1.96) | 0.83 | ||
| Dyslipidemia | 1.02 (0.61–1.73) | 0.93 | ||
| Diabetes | 1.07 (0.62–1.85) | 0.80 | ||
| Coronary artery disease | 1.35 (0.72–2.54) | 0.35 | ||
| Prior ischemic stroke | 1.16 (0.61–2.22) | 0.65 | ||
| Atrial fibrillation | 3.14 (1.80–5.50) | < 0.001 | 1.22 (0.75–1.99) | 0.41 |
| Tobacco use | 0.44 (0.15–1.23) | 0.12 | ||
| Heart failure | 2.14 (1.08–4.23) | 0.03 | 1.77 (0.65–4.82) | 0.27 |
| NIHSS, per point | 1.15 (1.11–1.19) | < 0.001 | 1.15 (1.12–1.17) | < 0.001 |
| Large vessel occlusion | 1.58 (0.90–2.78) | 0.11 | ||
| sICHb | 8.43 (3.81–18.63) | < 0.001 | 8.06 (4.14–15.70) | < 0.001 |
OR denotes odds ratio (with 95% confidence interval), COVID-19 coronavirus disease 2019, NIHSS National Institutes of Health Stroke Scale, and sICH symptomatic intracerebral hemorrhage within 36 h of thrombolysis
aFinal multivariable model shown is inclusive of the interaction term for treatment delay on admission during the COVID-19 period (AIC 284.28)
bsICH was defined using NINDS criteria as any neurologic worsening attributed to an intracranial hemorrhage which occurred within 36 h of thrombolysis