TABLE III.

Summary of the representative publications for nanocarriers enhancing aqueous solubility of phthalocyanine/naphthalocyanine nanoparticles. $\overline{d}$, mean diameter; PEG, polyethylene glycol, ${\lambda }_{\text{max}}$, maximum absorption wavelength; $ϵ$, molar extinction coefficient; ${\Phi }_F$, fluorescence quantum yield; ${\Phi }_{\Delta }$, singlet oxygen generation quantum yield; SERS, Surface-enhanced Raman spectroscopy; $\eta$, photothermal conversion coefficient; PDT, photodynamic therapy; PTT, photothermal therapy.

Group	Nanomaterial	Carrier type	Excipient type	$\overline{d}$ (nm)	Major features
Choi et al.70	Nc/PFH@PCPN	Block copolymer micelle	Six-arm PEG-amine crosslinked Pluronic F127	500–2500	• ${\lambda }_{\mathit{\text{max}}}$ = 850 nm
					• 89.4 % 14-day sustainability (37 °C)
Rizvi et al.89	ZnPc (tomamine)n	Block copolymer micelle	Tomamine	89 ± 8;	• ${\lambda }_{\mathit{\text{max}}}$ [nm] = 774; 810; 805; 820
				133 ± 7;	• $ϵ$ [O.D.] = 3.60; 3.49; 3.38; 3.25
				193 ± 10;	• ${\Phi }_F$ ≪ 1
				223 ± 9;	• ${\Phi }_{\Delta }$< 0.01
					• strong SERS signal
Zhang et al.91	Nanonap	Block copolymer micelle	Pluronic F127	29.5	• Surfactant-stripped micelle
					• ${\lambda }_{\mathit{\text{max}}}$ = 860 nm
					• PTT with upconversion cream,
					• PET application with 64Cu chelation
Wei et al.58	SiNcOH-DSPE-PEG(NH2)	phospho-lipid micelle	PEG-conjugated phospholipid	160	• $\eta$ = 59.8 %
					• 7-day stability
Ma et al.92	ZnPc-SPC	Liposome	ZnPc-soybean phospholipid complex	296.9 ± 6.553	• Drug loading (doxorubicin)
					• Folate receptor(FRα),
					• max. 15 day stability
Li et al.93	Pc-petide conjugate self-assembly	Short Petide micelle	L-phenylalanine-L-phenylalanine	54.8 ± 17.6 (pH 7.0)	• Theranostic application (PDT/PTT)
					• pH dependent nanoparticle size
					• Switchable photoactivity with cell membrane interaction