. 2021 Jul 30;5(3):031510. doi: 10.1063/5.0047660

TABLE VIII.

Summary of the representative publications for phototherapy with phthalocyanine/naphthalocyanine nanoparticles. PA, photoacoustic; PTT, photothermal therapy; FL, fluorescence; NIR, near infrared; PAT, photoacoustic therapy; PDT, photodynamic therapy.

Group	Agent	Phototherapy parameters	Application	Major features
Li et al.⁵⁴	PcS4-PcN4	660 nm, 2 W·cm⁻², 8 min	PA image-guided PTT	• Completely quenched FL, leading to strong PA/PTT responses
Pan et al.⁵⁶	Zn₄-H₂Pc/DP NPs	1064 nm, 0.6 W·cm⁻², 10 min	PA image-guided PTT	• Phototheranostic agent in NIR-II window
Du et al.¹¹³	DBCO-ZnPc-LP	808 nm, 0.1 W·cm⁻², 5 min	PA image-guided PTT/PAT	• Strong heat energy transfer for PTT
Du et al.¹¹³	DBCO-ZnPc-LP	808 nm, 0.1 W·cm⁻², 5 min	PA image-guided PTT/PAT	• Thermal-enhanced ultrasonic shockwave for PAT
Ding et al.⁵⁷	FA-ZnPcNDs	808 nm, 0.5 W·cm⁻², 3 min	PA image-guided PDT	• Excellent water solubility and stealth properties
Li et al.¹¹⁶	NanoPcTBs	655 nm, 2.0 W·cm⁻², 1 min. + 0.22 W·cm⁻², 5 min	PA/FL image-guided PTT/PDT	• Activatable in biotin receptor-positive cancer cells
				• Intrinsic PA+PTT properties
				• Cancer-specifically activating FL+PDT properties
Mauriello-Jimenez et al.¹²²	BSPOR, BSPHT	750 nm, 800 nm, 3 W, 1.57 s	PA image-guided PDT	• Two-photon excited PDT for precise treatment in deep tissues.