Table 1.
Organ weight/body weight ratio | Body weight (g) | ||||||
---|---|---|---|---|---|---|---|
Spleen | Liver | Kidney | Pancreas | Initial | Final | % change in body weight | |
Control | 0.005 ± 3.7 × 10−5 | 0.043 ± 3.0 × 10−4 | 0.005 ± 3.2 × 10−4 | 0.004 ± 2.6 × 10−5 | 153.6 ± 14.5 | 154.5 ± 17.4 | 0.58 |
Model | 0.005 ± 1.6 × 10−4 | 0.032 ± 1.0 × 10−3 | 0.004 ± 1.3 × 10−4 | 0.005 ± 1.6 × 10−4 | 167.4 ± 23.8 | 156.4 ± 8.0 | -6.57a |
Metformin (mg/kg) | 0.005 ± 1.2 × 10−4 | 0.042 ± 1.0 × 10−3 | 0.004 ± 1.0 × 10−4 | 0.002 ± 5.5 × 10−4 | 167.2 ± 52.9 | 163.1 ± 11.2 | -0.02ns |
APLE (mg/kg) | |||||||
100 | 0.006 ± 1.6 × 10−4 | 0.050 ± 1.0 × 10−3 | 0.006 ± 1.6 × 10−4 | 0.005 ± 1.4 × 10−4 | 138.5 ± 32.4 | 145.5 ± 62.6 | 5.10b |
200 | 0.006 ± 2.3 × 10−4 | 0.055 ± 2.0 × 10−3 | 0.006 ± 2.4 × 10−4 | 0.004 ± 1.4 × 10−4 | 146.6 ± 43.5 | 140.9 ± 21.5 | -3.86ns |
400 | 0.005 ± 2.3 × 10−4 | 0.031 ± 1.0 × 10−3 | 0.003 ± 1.3 × 10−4 | 0.005 ± 2.0 × 10−4 | 156.2 ± 23.0 | 154.6 ± 24.9 | -0.99ns |
∗Received normal saline; APLE: Abrus precatorius leaf extract (APLE); ns: not significant; aP ≤ 0.05 (model vs. control); bP ≤ 0.05 (APLE and metformin vs. model).