Table 1.
Intrinsic excitability in wild-type and SRKO CA1 pyramidal neurons
| Property | Wild Type (n = 12) | SRKO (n = 13) | Student’s t Test (unpaired) | P Value |
|---|---|---|---|---|
| RMP, mVa | 60.6 ± 0.5 [−65 to −55] |
−60.8 ± 0.5 [−65 to −55] |
t(48) = 0.34 | 0.736 |
| Rinput, MΩ | 174.6 ± 13.0 [97.7 to 235.8] |
154.0 ± 9.9 [89.4 to 219.3] |
t(23) = 1.27 | 0.216 |
| Sag, mVb | −0.20 ± 0.001 [−0.17 to −0.24] |
−0.22 ± 0.01 [−0.14 to −0.26] |
t(23) = 1.27 | 0.219 |
| Rheobase, pA | 15.1 ± 5.1 [2.7 to 59.3] |
25.2 ± 4.8 [2.7 to 70.2] |
t(23) = 1.45 | 0.159 |
| AP threshold, mVb | 49.2 ± 0.8 [−44.3 to −52.7] |
−50.4 ± 0.6 [−44.8 to −53.1] |
t(23) = 1.19 | 0.247 |
| AP height, mV | 120.9 ± 2.3 [105 to 140] |
120.9 ± 1.7 [110 to 134] |
t(23) = 0.01 | 0.989 |
| AHP peak, mV | −2.79 ± 0.4 [−5.75 to −0.845] |
−1.60 ± 0.3 [−3.74 to −0.46] |
t(23) = 2.35 | 0.028* |
Means ± SE [range].
a
For RMP: wild-type n = 27, SRKO n = 23.
bJunction potential not adjusted. AHP, afterhyperpolarization; AP, action potential; Rinput, input resistance; RMP, resting membrane potential; SRKO, serine racemase knockout; *P < 0.05.