Table 3.
Clinical functional measures and muscle fat fraction of participants with Duchenne muscular dystrophy and unaffected controls
| Controls | DMD | P Value | |
|---|---|---|---|
| Functional test | |||
| 6MWD, m | 514 (469, 558) | 389 (203, 375) | <0.0001 |
| 10 m walk/run, s | 2.8 (2.6, 3.0) | 9.0 (3.7, 14.3) | <0.0001 |
| Muscle CSA, cm2 | |||
| TA | 3.25 (2.57, 3.92) | 3.26 (2.73, 3.78) | 0.430 |
| EDL | 1.43 (1.16, 1.70) | 1.54 (1.16, 1.92) | 0.602 |
| Fat fraction, % | |||
| TA | 8.9 (7.4, 10.5) | 16.3 (11.6, 21.0) | <0.0001 |
| EDL | 7.7 (6.6, 8.7) | 17.1 (11.2, 23.0) | <0.0001 |
Values are expressed as mean (lower and upper 95% confidence interval; C95). Welch’s unpaired two-tailed t test was used to compare DMD (n = 15) and unaffected controls (n = 15). CSA, cross-sectional area; DMD, Duchenne muscular dystrophy; EDL, extensor digitorum longus; TA, tibialis anterior; 6MWD, 6-min walk distance.