Table 3.
Firefighter urine biomarker concentrationsA (μg/g creatinine) by job assignment compared to the general population (GP).
Pre-fire Concentration | 3-Hour Post-fire Concentration |
6-Hour Post-fire Concentration |
12-Hour Post-fire Concentration | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Biomar ker |
Job Assignment | N (N < LODB) |
GM (GSD) |
P-value (vs. GP) |
N (N < LODB) |
GM (GSD) |
P-value (vs. GP) |
N (N < LODB) |
GM (GSD) |
P-value (vs. GP) |
N (N < LODB) |
GM (GSD) |
P-value (vs. GP) |
DPhP | All Firefighters | 36 (3) |
0.97 (1.98) |
0.103 | 36 (3) |
1.67 (1.94) |
<0.001E | 36 (0) |
1.58 (1.96) |
<0.001E | 36 (1) |
1.20 (2.13) |
0.003D |
Exterior | 12 (2) |
0.95 (2.37) |
0.489 | 12 (1) |
1.55 (2.05) |
0.009E | 12 (0) |
1.38 (2.15) |
0.032 | 12 (0) |
1.22 (2.18) |
0.088 | |
Interior | 12 (1) |
1.04 (1.92) |
0.196 | 12 (1) |
1.72 (2.11) |
0.005E | 12 (0) |
1.66 (2.31) |
0.012 | 12 (0) |
1.28 (2.53) |
0.105 | |
Overhaul | 12 (0) |
0.92 (1.74) |
0.403 | 12 (1)** |
1.75 (1.75)** |
<0.001E | 12 (0)** |
1.72 (1.43)** |
<0.001E | 12 (1)** |
1.10 (1.78)** |
0.080 | |
General PopulationC | 1901 (187) |
0.80 (2.59) |
Reference | Reference | Reference | Reference | |||||||
BDCPP | All Firefighters | 36 (0) |
2.38 (2.12) |
<0.001E | 36 (0) |
2.70 (1.97) |
<0.001E | 36 (0) |
2.57 (2.01) |
<0.001E | 36 (0) |
2.13 (1.99) |
0<.001E |
Exterior | 12 (0) |
2.73 (2.22) |
<0.001E | 12 (0) |
3.32 (2.11) |
<0.001E | 12 (0) |
2.63 (2.07) |
<0.001E | 12 (0) |
2.23 (1.97) |
0<.001E | |
Interior | 12 (0) |
2.09 (2.10) |
0.003E | 12 (0) |
2.25 (1.83) |
<0.001E | 12 (0) |
2.07 (1.98) |
<0.001E | 12 (0) |
1.86 (2.06) |
0.002E | |
Overhaul | 12 (0) |
2.38 (2.13) |
<0.001E | 12 (0)** |
2.64 (1.95)** |
<0.001E | 12 (0)** |
3.11 (1.96)** |
<0.001E | 12 (0)** |
2.33 (2.01)** |
0<.001E | |
General PopulationC | 1886 (174) |
0.79 (2.83) |
Reference | Reference | Reference | Reference | |||||||
BCEtP | All Firefighters | 36 (6) |
0.28 (3.01) |
0.048D | 36 (8) |
0.34 (2.09) |
0.117 | 36 (1) |
0.36 (1.83) |
0.170 | 36 (5) |
0.20 (2.03) |
<0.001D |
Exterior | 12 (2) |
0.47 (2.43) |
0.630 | 12 (2) |
0.38 (1.94) |
0.701 | 12 (1) |
0.37 (1.75) |
0.538 | 12 (2) |
0.23 (1.81) |
0.005D | |
Interior | 12 (3) |
0.24 (2.92) |
0.119 | 12 (4) |
0.33 (2.10) |
0.302 | 12 (0) |
0.33 (1.78) |
0.195 | 12 (1) |
0.17 (2.51) |
0.006D | |
Overhaul | 12 (1) |
0.20 (3.37) |
0.058 | 12 (2)** |
0.31 (2.34)** |
0.256 | 12 (0)** |
0.37 (2.02)**Ga |
0.641 | 12 (2)** |
0.21 (1.82)** |
0.002D | |
General PopulationC | 1897 (240) |
0.41 (3.10) |
Reference | Reference | Reference | Reference |
Metabolites with less than 60% detection rate are summarized in Supplemental Materials (Table S2).
Limit of detection (LOD) for each analyte in μg/L: DPhP=0.16, BDCPP=0.11, BCEtP=0.08.
Ospina, M., Jayatilaka, N., Wong, L.-Y., Restrepo, P., Calafat AM., 2018 Exposure to organophosphate flame retardant chemicals in the U.S. general population: Data from the 2013–2014 National Health and Nutrition Examination Survey. Environmental International. 110, 32-41. Participants aged 18 and older are included.
Results were significantly lower than the general population.
Results were significantly higher than the general population.
GM and GSD of general population were listed in the pre-fire columns.