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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Biomaterials. 2021 Jun 10;275:120968. doi: 10.1016/j.biomaterials.2021.120968

Figure 3. IH-mitigating effect of rapamycin periadventitially delivered through crosslinked (Mode-1) or non-crosslinked UM (Mode-2).

Figure 3.

The open surgery of rat common carotid artery angioplasty followed by periadventitial application of UM (without or with rapamycin) was described in Methods. At post-surgery 14 days arteries were harvested for cross-section preparation and H&E staining. (A) Representative H&E-stained artery cross-sections. Scale bar: 200 μm. (B) High-mag images. Scale bar: 50 μm. (C) Morphometric quantification: mean ± SEM, n = 6–8 rats, as indicated by the data points in each plot. Statistics: ANOVA and Bonferroni test: *P <0.05. r.u., relative unit. The calculation of I/M ratio, normalized intimal thickness, and stenosis rate are described in Methods.