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. 2021 Jul 31;38(9):105. doi: 10.1007/s12032-021-01554-2

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Comparison of the mRNA abundance in benign kidney EVs, ccRCC EVs, and pRCC EVs. Heatmap of top 100 differentially expressed genes using unsupervised clustering demonstrates unique expression patterns for EVs from each subtype (benign, ccRCC, and pRCC). Upregulated genes are in red and downregulated in blue. c. Volcano plots demonstrating fold changes of differential gene expression between ccRCC EVs and benign kidney EVs (Data are reported as x-axis = log₂ fold change, y-axis = p value, dashed lines represent p-value cutoffs of 10e−6, 10e−8, and 10e−5). d GSEA plots of Nanostring gene sets enriched in ccRCC or benign EVs (Significance determined as p < 0.05. FDR < 0.25)