Skip to main content
. 2021 Jul 8;53(8):1257–1268. doi: 10.1007/s00726-021-03030-7

Table 2.

Cytotoxicity (EC50) of studied compounds to selected cell lines

Compound EC50 [μM]
No. Designation Rat glioma
(C6)		 Mouse fibroblasts
(A9)		 Human dermal fibroblasts (HDF) Human embryonic kidney
(Hek293)
1 H-Box[(4-Me)Ph]-OMe 309 ± 7 nd nd nd
2 H-Box[(4-F)Ph]-OMe 372 ± 3 nd nd nd
3 H-Box[(4-CN)Ph]-OMe 286 ± 7 nd nd nd
4 H-Box[(4-COOH)Ph]-OMe No effect nd nd nd
5 H-Box[(4-Br)Ph]-OMe 230 ± 1 80 ± 5 46 ± 0.3 238 ± 15
6 H-Box[(2-OMe)Ph]-OMe 438 ± 20 334 ± 22 100 ± 2 718 ± 92
7 H-Box[2,5-(OMe)2Ph]-OMe 900 ± 21 354 ± 33 60 ± 4 256 ± 21
8 H-Box[2,4,5-(OMe)3Ph]-OMe 832 ± 58 1700 ± 25 238 ± 9 745 ± 135
9 H-Box[3,4,5-(OMe)3Ph]-OMe 317 ± 36 1459 ± 19 81 ± 5 878 ± 70
10 H-Box[(4-OAll)Ph]-OMe 185 ± 4 nd nd nd
11 H-Box[(4-NMe2)Ph]-OMe 277 ± 6 nd nd nd
12 H-Box[(4-NPh2)Ph]-OMe –a nd nd nd
13 H-Box[(2-OMe-4-NMe2)Ph]-OMe 239 ± 11 97 ± 3 29 ± 1 314 ± 15
14 H-Box[(2-OH-4-NEt2)Ph]-OMe 337 ± 8 nd nd nd
15 H-Box[2,4-(OH)2Ph]-OMe No effect nd nd nd
16 H-Box[(4-B(OH)2)Ph]-OMe 299 ± 8 627 ± 26 101 ± 18 Not toxicb
17 H-Box[(3-B(OH)2)Ph]-OMe 59 ± 3 62 ± 7 88 ± 15 672 ± 58
18 H-Box[(3-OPh)Ph]-OMe No effect nd nd nd
19 H-Box[3,5-(CF3)2Ph]-OMe –a nd nd nd
20 H-Box(4-NMe2Cin)-OMe 229 ± 5 nd nd nd
21 H-Box(Fur)-OMe 450 ± 10 nd nd nd
22 H-Box(Tio)-OMe 954 ± 44 nd nd nd
23 H-Box(Pyrrol)-OMe 418 ± 48 278 ± 32 110 ± 2 852 ± 80
24 H-Box(Indol)-OMe –a nd nd nd
25 H-Box(Benzotio)-OMe 79 ± 7 53 ± 1 6 ± 0.4 437 ± 32
26 H-Box(4Py)-OMe 1866 ± 86 1174 ± 21 112 ± 9 4099 ± 131
27 H-Box(2Py)-OMe 983 ± 2 662 ± 49 296 ± 9 1429 ± 104
28 H-Box(2Q)-OMe 131 ± 5 50 ± 3 37 ± 0.1 326 ± 19
29 H-Box(3Q)-OMe 299 ± 24 51 ± 3 21 ± 1 378 ± 18
30 H-Box(3iQ)-OMe 147 ± 3 58 ± 4 54 ± 3 290 ± 10
31 H-Box(6Q)-OMe –a nd nd nd
32 H-Box(4Q)-OMe 567 ± 20 106 ± 10 26 ± 2 583 ± 29
33 H-Box(8Q)-OMe 377 ± 22 313 ± 22 394 ± 9 198 ± 5
34 H-Box(4PyBr)-OMe 1760 ± 8 408 ± 3 73 ± 12 3216 ± 171
35 H-Box(2PyBr)-OMe 965 ± 44 234 ± 21 48 ± 4 1980 ± 112
36 H-Box[(4-Me)Ph]-OH No effect nd nd nd
37 H-Box(BiPh)-OH No effect nd nd nd
38 H-Box(2-Naph)-OH No effect nd nd nd
39 H-Box(9-Ant)-OH 320 ± 15 nd nd nd
40 H-Box(2-Im)-OH No effect nd nd nd
41 H-Box(2-Benzofur)-OH No effect nd nd nd

nd not determined

aToo low solubility in the conditions of the experiment

bIn the concentration range of 10–2500 μM