Table 3.

Association between the presence of anti-HSV IgG and hippocampal volume or white matter integrity.

	All subjects, n = 330 or 243a,b					APOE4-positive subjects, n = 69 or 51a,c				APOE4-negative subjects, n = 262 or 193a,c
	Numbers of IgG negative/positive subjects	β	SD	p-value	Interaction with APOE4 (p-value)	Numbers of IgG negative/positive subjects	β	SD	p-value	Numbers of IgG negative/positive subjects	β	SD	p-value
Hippocampal volume (% TIV)	62/268	−0.006	0.004	0.19	0.15	14/55	−0.016	0.009	0.09	48/214	−0.002	0.005	0.71
Parahippocampal cingulum	47/196					11/40				36/157
Fractional anisotropy		−0.014	0.006	0.02	0.64		−0.014	0.014	0.30		−0.012	0.006	0.05
Mean diffusivity (in 10−6 mm2/s)		12	6	0.04	0.65		11	12	0.36		10	6	0.09
Axial diffusivity (in 10−6 mm2/s)		1	9	0.89	0.73		4	19	0.83		−1	10	0.91
Radial diffusivity (in 10−6 mm2/s)		17	6	0.009	0.72		15	15	0.32		15	7	0.01
Parahippocampal fornix	47/196					11/40				36/157
Fractional anisotropy		−0.016	0.006	0.009	0.33		−0.025	0.014	0.07		−0.013	0.007	0.06
Mean diffusivity (in 10−6 mm2/s)		31	11	0.005	0.62		36	19	0.07		25	13	0.006
Axial diffusivity (in 10−6 mm2/s)		21	13	0.11	0.98		16	24	0.50		16	15	0.28
Radial diffusivity (in 10−6 mm2/s)		37	12	0.002	0.49		46	22	0.04		30	13	0.03

Adjusted linear regression models. 3C and AMI cohorts.

TIV total intracranial volume, SD standard deviation.

^aNumber of subjects included in the analysis of hippocampal volume and white matter integrity, respectively (19 and 16 subjects had missing data for APOE4 or hypertension).

^bAdjusted for age at serology, sex, level of education, presence of at least one allele of APOE4, hypertension, diabetes, and cohort.

^cAdjusted for age at serology, sex, and cohort.

Bold values are statistically significant results.