Table 4.

Association between HSV status and the incidence of Alzheimer’s disease—adjusted Cox models.

	All subjectsa (n = 1528 including 212 cases or n = 1269 including 181 cases)c				APOE4-positive subjectsb (n = 271 including 54 cases or n = 222 including 49 cases)d			APOE4-negative subjectsb (n = 1274 including 161 cases or n = 1062 including 135 cases)d
	aHR	95% CI	p-value	Interaction with APOE4 (p-value)	aHR	95% CI	p-value	aHR	95% CI	p-value
Anti-HSV IgG + (vs −)	1.19	0.81–1.77	0.38	0.05	2.72	1.07–6.91	0.04	0.92	0.60–1.42	0.72
IgG levels in terciles (in all subjects)e			0.37	0.12			0.02			0.98
1st tercile (vs negative IgG)	0.99	0.62–1.59	0.98		1.70	0.57–5.05	0.34	0.89	0.53–1.49	0.66
2nd tercile (vs negative IgG)	1.21	0.76–1.92	0.42		2.41	0.85–6.81	0.10	0.93	0.55–1.56	0.78
3rd tercile (vs negative IgG)	1.32	0.87–2.03	0.20		3.87	1.45–10.28	0.007	0.94	0.58–1.51	0.79
IgG levels in terciles (in IgG+ subjects)e			0.29	0.42			0.08			0.95
2nd tercile (vs 1st tercile)	1.22	0.81–1.84	0.35		1.43	0.63–3.25	0.40	1.05	0.66–1.69	0.84
3rd tercile (vs 1st tercile)	1.35	0.93–1.97	0.12		2.30	1.08–4.91	0.03	1.07	0.70–1.64	0.75

3C and AMI cohorts.

aHR adjusted hazard ratio, 95% CI 95% confidence interval.

^aAdjusted for sex, level of education, marital status, presence of at least one allele of APOE4, hypertension, diabetes, hypercholesterolemia, tobacco use, and cohort.

^bAdjusted for sex, level of education, and cohort.

^cNumber of subjects for analysis in the whole sample or in the subsample of IgG+ subjects, respectively. Among them, 71 and 58 participants had missing data for the adjustment variables, respectively, including 54 and 43 participants with missing data for APOE4.

^dNumber of subjects for analysis in the whole sample or in the subsample of IgG+ subjects, respectively.

^eIgG levels in the 1st tercile were <17.7, in the 2nd tercile were ≥17.7 and <27.9, and in the 3rd tercile were ≥27.9.

Bold values are statistically significant results.