Female mice trended toward a decrease in immobility after ketamine in the forced test. Immobility behavior (72 hours post-injection) was automatically scored. Females showed lower immobility than males. Females, especially those exposed to UCS, showed a trend toward an therapeutic-like response to ketamine. Error bars: ± SEM. Three-way ANOVA, main effect of sex: ** p < 0.01, Two-way ANOVA, main effect of drug: * p = 0.052.