Table 4.
Effect estimates of dynamic arterial elastance for predicting the mean arterial pressure response to fluid expansion
| Variables | Subgroups | No. of studies | AUHSROC | Sensitivity (%) | Specificity (%) | Diagnostic odds ratio |
|---|---|---|---|---|---|---|
| Primary analysis | All studies | 8 | 0.92 (0.89, 0.94) | 0.85 (0.71, 0.93) | 0.85 (0.69, 0.94) | 22.8 (5.5, 93.6) |
| Classification of patients | ICU patients | 5 | 0.96 (0.94, 0.98) | 0.92 (0.75, 0.98) | 0.92 (0.82, 0.97) | 76.3 (13.0, 448.9) |
| Surgical patients in the operating room | 3 | 0.72 (0.67, 0.75) | 0.69 (0.56, 0.80) | 0.66 (0.48, 0.81) | 4.5 (1.3, 14.9) | |
| Fluid type | Colloid | 4 | 0.90 (0.87, 0.93) | 0.81 (0.60, 0.92) | 0.88 (0.58, 0.98) | 19.4 (2.2, 174.1) |
| Crystalloid | 4 | 0.93 (0.90, 0.95) | 0.89 (0.65, 0.97) | 0.85 (0.62, 0.95) | 30.0 (3.4, 248.7) | |
| Measurement technique | Arterial waveform analysis | 5 | 0.92 (0.90, 0.94) | 0.85 (0.58, 0.96) | 0.87 (0.61, 0.97) | 19.1 (2.6, 139.8) |
| Oesophageal Doppler | 2 | 0.90 (0.87, 0.92) | 0.85 (0.66, 0.94) | 0.80 (0.49, 0.94) | 21.8 (1.0, 458.4) | |
| PICCO | 1 | – | – | – | – | |
| Sensitivity analyses | Excluding the outlier* | 7 | 0.88 (0.85, 0.91) | 0.80 (0.68, 0.89) | 0.83 (0.66, 0.92) | 15.3 (4.0, 59.2) |
| Excluding 2 retrospective studies | 6 | 0.94 (0.91, 0.96) | 0.88 (0.71, 0.95) | 0.87 (0.71, 0.95) | 30.1 (6.5, 138.6) |
MAP mean arterial pressure, ICU intensive care unit, AUHSROC area under hierarchical summary receiver operating characteristic curve, PICCO pulse indicator continuous cardiac output
* The study by Guarracino et al. was identified as the outlier based on a Galbraith plot