Fig. 6.

Effect of MSC-IL-Exo on the IκBα level in SW982 cells treated with IL-1β and TNF-α. SW982 cells were treated with IL-1β (10 ng/mL) and TNF-α (25 ng/mL) in the presence of 10 μg/mL MSC-IL-Exo or after transfection of miR-147b mimics or miR-147b inhibitor. Protein levels of IκBα was examined via Western blot analysis at 30 min, 1 h, and 24 h. β-actin was used as an internal control. Intensities of IκBα signal were quantified, and their normalized values by that of β-actin are presented in the graph as mean ± SD from three independent experiments (n = 3). ^#/*p < 0.05, ^##p < 0.01, and ^###p < 0.001 for three treatment groups (MSC-IL-Exo, miR-147b mimics, and miR-147b inhibitor) versus untreated control (^#) or versus IL-1β and TNF-α groups (*) by one-way ANOVA