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. 2021 Jun 24;3(1):vdab085. doi: 10.1093/noajnl/vdab085

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© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Tissue analysis of in vivo meningioma xenografts. (A) Mitosis counts in CH157 and IOMM-Lee intracranial tumors (open and filled symbols, respectively), following 5 days of radiation therapy (RT: 2 Gy/day × 5), palbociclib therapy (150 mg/kg/day × 5), or concurrent RT + palbociclib for 5 consecutive days. Each data point represents the average number of positive cells counted in 10 high-powered fields (400x) of a single intracranial tumor. *P < 0.05 versus all other groups, as indicated by one-way ANOVA analysis. (B) Representative photomicrographs of CH157 (upper panels) and IOMM-Lee (lower panels) intracranial xenografts. Mitoses are identified by arrowheads. Scale bar = 50 microns. (C) Same specimens as analyzed in (B), but examined for apoptotic cells, P = 0.082 via one-way ANOVA.