Table 4.
Top 10 transcripts underexpressed in ileal mucosa ranked by increasing absolute log2 fold change (logFC) in asthma vs controls. FDR—false-discovery ratio (Benjamini-Hochberg)
| logFC | Average expression | pFDR | Gene | Gene name and function |
|---|---|---|---|---|
| − 1.93 | 6.94 | 0.028 | LOC440525 | Probe ILMN_1662409—unknown function; increased expression in the intestine after congenital heart defect surgery |
| − 1.92 | 7.86 | 0.017 | LOC731789 | Probe ILMN_3233239—unknown function; related to rs11015207 that associates with maximal oxygen uptake response after training |
| − 1.85 | 7.91 | 0.009 | PDE4A | Phosphodiesterase 4A—regulates cellular cyclic adenosine monophosphate (cAMP); related to asthma; asthma drug target |
| − 1.84 | 9.00 | 0.017 | LOC100129201 | Probe ILMN_3263918—unknown function; might be hypertension-related |
| − 1.84 | 7.31 | 0.036 | PCK1 | Phosphoenolpyruvate Carboxykinase 1—controls gluconeogenesis; regulates the citric acid cycle |
| − 1.78 | 7.67 | 0.016 | TAF13 | TATA-Box Binding Protein Associated Factor 13—involved in initiation of transcription by RNA polymerase II; its mutations associate with schizophrenia |
| − 1.76 | 6.70 | 0.027 | LOC100130422 | Probe ILMN_3242709—function unknown |
| − 1.74 | 8.55 | 0.033 | HINT3 | Histidine Triad Nucleotide Binding Protein 3—may act on alpha-phosphate of ribonucleotides |
| − 1.74 | 7.13 | 0.017 | KREMEN2 | Kringle Containing Transmembrane Protein 2—by enhancing endocytosis of LRP5 and LRP6 inhibits signalling through Wnt/β-catenin pathway |
| − 1.71 | 7.90 | 0.017 | TAF13 | TATA-Box Binding Protein Associated Factor 13 |