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. 2021 Jul 31;13:150. doi: 10.1186/s13148-021-01139-w

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© The Author(s) 2021, corrected publication 2021

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Fig. 2 — Chromatin loop formation in GSC differentiation. GSCs present a more relaxed and accessible chromatin state with permissive interactions between enhancers and promoters among different domains. During GSC differentiation, loss of stemness in non-stem glioma cells (NSGC) correlates with increased chromatin-loop formation, adopting a more restricted chromatin conformation with strong domain boundaries and limited enhancer–promoter interactions