Figure 3. Compound 2 increases susceptibility to colistin.

(A) P. aeruginosa PA14 was treated for 17 h with increasing amounts of colistin in the presence of no added inhibitor (DMSO, circles) or 50 μM inhibitor 2 (triangles). (B) P. aeruginosa PA14 was treated with increasing amounts of inhibitor 2 in the presence of no added colistin (water, circles) or 0.375 μg/mL colistin (triangles). (A-B) Cell viability was tracked by OD600. Error bars represent the standard deviation of the mean of three replicates.