TABLE 1.
Definitions of outcome measures1
| Definitions | |
|---|---|
| activity_level.11 | Parent-reported child activity level from the CBCL (short form) at 9 mo; range = 1 to 7, higher scores indicate higher levels of activity |
| blood_pressure_diastolic.1 | Diastolic blood pressure at baseline (0 mo) |
| blood_pressure_diastolic.8 | Diastolic blood pressure at 6 mo |
| bloodlevel_betaine.1 | Plasma betaine concentrations at baseline (0 mo) |
| delta_adjpairs_imm | Change in Elicited Imitation immediate memory task performance (for pairs of items regardless of sequence order) between baseline (0 mo) and 9 mo; higher scores indicate greater positive change (improvement) |
| delta_imt_v1_v13_adjpairs | Change in Elicited Imitation memory task performance (for pairs of adjacent items in the correct sequence order) between baseline (0 mo) and 4-y follow-up; higher scores indicate greater positive change (improvement) |
| delta_pairs_imm | Change in Elicited Imitation immediate memory task performance (pairs) between baseline (0 mo) and 9 mo; higher scores indicate greater positive change (improvement) |
| heart_rate.11 | Resting heart rate at 9 mo |
| height_physical.11 | Height taken during physical examination at 9 mo |
| height_pile_physical.1 | Age-adjusted height percentile at baseline (0 mo) |
| height_pile_physical.11 | Age-adjusted height percentile at 9 mo |
| height_z_physical.1 | z Score for age-adjusted height at 0 mo |
| height_z_physical.11 | z Score for age-adjusted height at 9 mo |
| ibb_tscore21 | CBCL parent-reported “sluggish cognitive tempo” at baseline (0 mo); age-corrected scores with higher scores indicating more problems |
| iib_avg_imt_adjpairs | Elicited Imitation memory task performance (adjacent pairs) at 4-y follow-up; higher scores indicate better memory performance |
| iib_tscore13 | CBCL parent-reported Externalizing problems at baseline (0 mo); age-corrected scores with higher scores indicating more problems |
| iib_tscore21 | CBCL parent-reported Conduct problems at baseline (0 mo); age-corrected scores with higher scores indicating more problems |
| ilb_avg_imt_pairs | Elicited Imitation memory task performance (pairs) at 4-y follow-up; higher scores indicate better memory performance |
| imt_adjpairs_imm_med.11 | Elicited Imitation immediate memory task performance (adjacent pairs) at 9 mo; higher scores indicate better memory performance |
| imt_comp_imm_med.1 | Elicited Imitation immediate memory task performance (components) at baseline (0 mo); higher scores indicate better memory performance |
| imt_comp_sd_avemh.11 | Elicited Imitation short-delay memory task performance (components) at 9 mo; higher scores indicate better memory performance |
| memfaces_delcontrastsc | NEPSY-II Memory for Faces—Immediate vs. Delayed contrast score at 4-y follow-up; age-adjusted scaled score with higher scores indicating better performance |
| memnames_t3total | NEPSY-II Memory for Names Trial 3 total score at 4-y follow-up; age-corrected scaled score with higher scores indicating better performance |
| nihdccs_agecorrstandsc | NIH Toolbox Dimensional Card Sorting test performance at 4-y follow-up; age-corrected standard score with higher scores indicating better performance |
| nihdccs_fullcorrtsc | NIH Toolbox Dimensional Card Sort Test performance at 4-y follow-up; fully corrected (age, education, gender, race/ethnicity) standard score with higher scores indicating better performance |
| nihpsmt_agecorrstandsc | NIH Toolbox Picture Sequence Memory Test performance at 4-y follow-up; age-corrected standard score with higher scores indicating better performance |
| stanfbi_fsiq | Stanford-Binet Intelligence Scale (5th edition) Full Scale Intelligence Quotient at 4-y follow-up; age-corrected scores with higher scores indicating higher ability |
| stanfbi_qr | Stanford-Binet Intelligence Scale (5th edition) Quantitative Reasoning Index at 4-y follow-up; age-corrected scores with higher scores indicating higher ability |
| stanfbi_viq | Stanford-Binet Intelligence Scale (5th edition) Verbal Intelligence Quotient at 4-y follow-up; age-corrected scores with higher scores indicating higher ability |
| stanfbi_wm | Stanford-Binet Intelligence Scale (5th edition) Working Memory index at 4-y follow-up; age-corrected scores with higher scores indicating higher ability |
| t_score_2.11 | CBCL parent-reported social problems at 9 mo; age-corrected scores with higher scores indicating more problems |
| t_score3.1 | CBCL parent-reported school problems at baseline (0 mo); age-corrected scores with higher scores indicating more problems |
| t_score8.11 | CBCL parent-reported thought problems at 9 mo; age-corrected scores with higher scores indicating more problems |
| weight_pile_physical.12 | Age-adjusted weight percentile at 0 mo |
| weight_pile_physical.32 | Age-adjusted weight percentile at 3 mo |
| weight_z_physical.12 | z Score for age-adjusted height at 0 mo |
| weight_z_physical.32 | z Score for age-adjusted height at 3 mo |
| weight_z_physical.82 | z Score for age-adjusted height at 6 mo |
| weight_z_physical.112 | z Score for age-adjusted height at 9 mo |
| weightheight_z_physical.12 | z Score for age-adjusted weight-height at 0 mo |
1
Child Behavior Checklist; NEPSY-II, NEuroPSYcological Assessment, second edition.
2
Height and weight were standardized using normative data (33).