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. 2021 Apr 19;114(2):617–627. doi: 10.1093/ajcn/nqab081

TABLE 3.

SNPs and effect alleles within SLC44A1 associated with improved cognitive outcome in choline-treated participants1

delta_pairs_imm2 delta_adjpairs_imm2  Number w/effect allele5
SNP P Reg. coeff.3 P Reg. coeff. Effect allele4
rs10123494 0.005672 −1.0505 0.000506 −1.1232 C (T > C) 10/22
rs10820801 0.005141 −1.0476 0.001469 −1.0872 G (A > G) 9/22
rs10991639 0.005141 −1.0476 0.001469 −1.0872 A (G > A) 9/22
rs2417615 0.005141 −1.0476 0.001469 −1.0872 A (G > A) 9/22
rs2771040 0.005141 −1.0476 0.001469 −1.0872 G (A > G) 9/22
rs3199966 0.049690 −1.0516 0.001285 −1.1981 G (T > G) 9/22
rs34750132 0.005672 −1.0505 0.000506 −1.1232 G (A > G) 10/22
rs35603631 0.005672 −1.0505 0.000506 −1.1232 C (T > C) 10/22
rs4549843 0.005141 −1.0476 0.001469 −1.0872 A (G > A) 9/22
rs6479311 0.005141 −1.0476 0.001469 −1.0872 A (C > A) 9/22
rs6479313 0.005672 −1.0505 0.000506 −1.1232 G (C > G) 10/22
rs7024985 0.003171 −1.0476 0.001469 −1.0872 T (C > T) 9/22
rs7029443 0.005672 −1.0505 0.000506 −1.1232 A (T > A) 10/22
rs7865985 0.005672 −1.0505 0.000506 −1.1232 C (T > C) 10/22
rs12339823 NS NS 0.004567 −1.1659 G (A > G) 7/22
rs16924529 NS NS 0.023036 −1.3298 A (G > A) 5/22
1

Reg. coeff., regression coefficient; SNP, single nucleotide polymorphism.

2

Associations between SNPs and outcomes were tested under an additive genetic model using the SNPassoc package in R (v.1.9–2). P values were adjusted for multiple testing using Bonferroni correction. Delta_pairs_imm is the change in Elicited Imitation immediate memory task performance (pairs) between baseline (0 mo) and 9 mo; delta_adjpairs_imm is the change in Elicited Imitation immediate memory task performance (adjacent pairs of items) between baseline (0 mo) and 9 mo.

3

Regression coefficient, extracted from additive model in SNPassoc package in R (v. 1.9–2).

4

Measured on top strand 5′→ 3′. Effect allele; major > minor allele within dbSNP.

5

Number of genotyped individuals carrying at least 1 copy of the effect allele within the choline cohort; 4 of the 26 children were missing this behavioral assessment and were excluded from this analysis.