Table 5.
Adipose tissue lipolytic sensitivity (−logEC50) to β-AR ligands1
| s.c. | i.m. | |
|---|---|---|
| LUB | 7.40 ± 1.782 | N.A.3 |
| BRL-37344 | 7.00 ± 3.27 | N.A. |
| SAL | 6.23 ± 0.35 | 4.59 ± 4.42 |
| SAL + LUB | 3.34 ± 0.59 *** | 8.07 ± 4.90 |
| SAL+ LUB + L-748,337 | 4.04 ± 0.34 *** | N.A. |
| DOB | 5.50 ± 0.68 | 6.52 ± 1.23 |
| DOB + LUB | 6.44 ± 3.20 | 7.29 ± 1.44 |
| DOB+ LUB + L-748,337 | 5.87 ± 0.81 | 6.12 ± 1.70 |
1The concentration of cAMP was determined using the Cyclic AMP XP Assay Kit according to the manufacturer’s instructions, as described in Table 2.
2Values are mean ± SEM of sensitivity of adipose tissue (−logEC50); n = 12 cattle. EC50 was calculated from the individual concentration-response to agonists fitted together by nonlinear regression. EC50, half maximum effective response.
3NA, not applicable. It was not possible to calculate EC50 from the data.
***P < 0.001, vs. SAL.