Figure 3:

Histopathology. (a) Hematoxylin and eosin (H&E) stain, ×40 and (b) ×20 showing a solid proliferation of atypical epithelioid cells with scattered pigmented melanophages amidst fibroconnective tissue. The samples are richly cellular with round to ovoid nuclei and prominent nucleoli. There are areas of necrosis with associated inflammation and hemorrhage. (c) Few spindle-shaped nests of cells admixed with melanophages were noted, ×40. (d) Ki-67 (MIB-1) index seen to be 1.5% with all other areas on ×40 found to be <4%. (e) HMB45/ Tyrosinase/MART-1 immunoperoxidase stain diffusely positive, ×40. (f) S-100 immunoperoxidase stain negative with interspersed dusty brown melanin pigment, ×40.