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Interaction of lncRNAs with components of tumor non-immune microenvironment. LncRNA PVT1 increased expression of TNF-α, IL-1β and IL-8 and promoted cell migration 9. LncRNA OLC8 bound to IL-11, and the complex significantly suppressed the degradation of IL-11 mRNAs, thus elevating IL-11 expression and promoting cell proliferation and migration 50. LncRNA ZFPM2-AS1 interacted with MIF and prevented degradation of MIF 51.
