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. 2021 Jul 13;17(11):2871–2883. doi: 10.7150/ijbs.60263

Figure 3.

Figure 3

Cardiac dysfunction and heart failure in Grx3 CKO DIO mice. In vivo echocardiography tracings of 10-m old chow diet- (n=6) and HFD-(n=8) fed controls and Grx3 CKO DIO mice showing left ventricular dilation and impaired contractility. Quantification of echo tracings revealed (A-B) increased left ventricular end-systolic diameters (LVESD), but not end-diastolic (LVEDD) in Grx3 CKO and Grx3 CKO DIO mice; (C-D) a significantly decline in ejection fraction (EF) and fraction shortening (FS) in Grx3 CKO and Grx3 CKO DIO mice compared to littermate controls. * p<0.5, ** p<0.01, and *** p<0.001 indicate a significance between Grx3 CKO mice and their littermate controls. # indicates a significance between chow diet- and HFD-fed Grx3 CKO mice.