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. 2021 Jun 26;17(11):2683–2702. doi: 10.7150/ijbs.61350

Figure 1.

Figure 1

TNF-α-regulated CXCL10/CXCR3 are highly expressed in CRC. (A) CXCL10 expression within CRC samples (T) and paired non-carcinoma samples (N). The data are from GEPIA, *p<0.01 versus control. (B) CXCR3 levels with normal and CRC tissues. Acquired images from the Human Protein Atlas online database. (C) Kaplan-Meier survival curve showing CRC survival curve for patients showing high or low CXCR3 level. (D) Association of TNF-α expression with CXCL10 gene levels within CRC and normal samples. Data were obtained from online GEPIA database. (E) The TNF-α-induced CXCL10 mRNA and protein levels at specific concentrations in SW480/SW620 cells were measured through ELISA and qPCR. (F) The TNF-α-induced CXCL10 mRNA and protein levels at specific time points in SW480/SW620 cells were measured through ELISA and qPCR (G) The CXCR3 mRNA expression induced by TNF-α in SW480/SW620 cells was detected by qPCR. Bar charts stand for mean ±SD (n=3). *p< 0.05, **p < 0.01 by Sidak multiple comparison test.