Table 2. Changes of blood count, blood chemistry parameteres, and inflammatory and oxidative markers between the TIV＋ PPSV23 and the TIV＋Placebo groups.
| TIV＋PPSV23 ( n = 19) | TIV＋Placebo ( n = 21) | |||||
|---|---|---|---|---|---|---|
| Baseline | 4 weeks | 12 weeks | Baseline | 4 weeks | 12 weeks | |
| Complete blood count | ||||||
| White blood cell count, 10 3 /mL | 6.0±1.9 | 6.3±2.0 | 5.9±1.5 | 6.0±1.1 | 5.9±1.4 | 5.9±1.2 |
| Hemoglobin, g/dL | 14.0±2.1 | 14.1±2.1 | 14.4±1.9 | 14.2±1.3 | 14.2±1.3 | 14.4±1.4 |
| Platelet, 10 3 /mL | 20.1±4.7 | 21.4±4.5 | 22.0±5.1 | 19.3±4.2 | 18.2±5.0 | 20.5±4.1 |
| Blood chemistry parameteres | ||||||
| Aspartate aminotransferase, U/L | 26±12 | 27±13 | 23±8 | 26±13 | 26±11 | 29±17 |
| Alanine aminotransferase, U/L | 25±15 | 26±16 | 22±11 | 29±18 | 29±17 | 29±17 |
| Lactate dehydrogenase, U/L | 197±36 | 193±32 | 191±31 | 187±34 | 184±29 | 184±29 |
| Blood urea nitrogen, g/dL | 16.8±5.0 | 18.2±5.8 | 16.3±5.7 | 16.2±4.2 | 16.7±3.2 | 16.4±3.7 |
| Creatinine, g/dL | 0.83±0.24 | 0.84±0.26 | 0.84±0.32 | 0.80±0.23 | 0.80±0.25 | 0.80±0.22 |
| Uric acid, mg/dL | 5.9±0.9 | 6.1±1.0 | 6.0±0.9 | 5.4±1.3 | 5.4±1.4 | 5.4±1.3 |
| Total cholesterol, mg/dL | 164±25 | 167±20 | 165±21 | 162±29 | 167±32 | 162±23 |
| Triglyceride, mg/dL | 151±78 | 145±52 | 153±62 | 131±85 | 131±62 | 131±56 |
| LDL-cholesterol, mg/dL | 83±21 | 83±21 | 86±19 | 91±25 | 83±21 | 88±24 |
| HDL-cholesterol, mg/dL | 50±15 | 50±12 | 49±12 | 48±11 | 49±13 | 48±10 |
| Fasting blood glucose, mg/dL | 125±35 | 129±64 | 117±36 | 127±30 | 128±39 | 123±35 |
| HbA1c, % | 6.3±0.8 | 6.4±0.8 | 6.5±0.8 | 6.2±0.7 | 6.3±0.8 | 6.4±0.7 |
| NT-proBNP, pg/mL | 431±638 | 404±559 | 373±663 | 236±537 | 187±286 | 164±269 |
| Inflammatory and oxidative markers | ||||||
| High-sensitivity CRP, mg/L | 1.21±1.45 | 1.65±2.33 | 2.97±5.63 | 0.90±1.53 | 1.00±1.32 | 1.46±0.95 |
| PTX-3, ng/mL | 1.88±0.98 | 1.91±0.78 | 1.86±1.17 | 1.94±0.91 | 1.88±0.71 | 1.88±0.95 |
| MDA-LDL, U/L | 110±27 | 113±41 | 124±48 | 103±34 | 103±35 | 109±36 |
| Anti-oxLDL, U/mL | 10070±4936 | 5541±1773 ＊ | 3879±2014 ＊＊＃ | 9410±7377 | 5704±1186 ＊ | 3540±864 ＊＊＃ |
Values are mean±SD. INF = influenza; PC = pneumococcal; CAD = coronary artery disease; LDL = low-density lipoprotein; HDL = high-density lipoprotein; CRP = C-reactive protein; PTX = pentraxin; NT-pro BNP = N-terminal pro brain natriuretic peptide; MDA = malondialdehyde; oxLDL = oxidized LDL
＊ P ＜0.05 compared with at baseline
＊＊ P ＜0.005 compared with at baseline
＃ P ＜0.05 compared with after 4 weeks