Fig. 9.

Several ceramide pathway genes are upregulated in psoriasis and functionally linked with the transcription factor ZIC1. Affymetrix CEL files from a psoriasis study were downloaded and genes in the ceramide pathway (Scheme 2) analyzed (17). Robust multiarray averaging-normalized gene expression level was corrected for multiple comparisons on a total of 50,683 probes (Benjamini-Hochberg test). Psoriasis plaque (PP), n = 64; psoriasis normal skin (PN), n = 58; healthy control normal skin (NN), n = 58. A: Box and whisker plots showing gene expression level for genes in the ceramide pathway which are significantly different. ∗ P < 0.05, ∗∗ P < 0.01, ∗∗∗ P < 0.005. B: IPA identifies many significantly different genes in the ceramide pathway link to ZIC1. Gene identifiers and expression values were uploaded for significant genes and network analysis performed (adjusted P value < 0.01). IPA, Ingenuity Pathway Analysis.