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. 2021 Aug 2;9:36. doi: 10.1038/s41413-021-00155-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Spinal pain hypersensitivity remained relieved after discontinuation of low-dose celecoxib treatment. a Spinal pain and endplate porosity were measured at 4 weeks after discontinuation of celecoxib or vehicle treatment. b Vocalization thresholds of the mice with LSI surgery at 4 weeks after the discontinuation of celecoxib or vehicle treatment. Spontaneous activity results, including distance traveled (c), active time per 24 h (d), and maximum speed (e). f, g The PWF in the von Frey test (0.07 g and 0.4 g). h Representative μCT images of the L4-L5 caudal endplates at 4 weeks after the discontinuation of celecoxib or vehicle treatment. Scale bars, 1 mm. Quantitative analysis of the total porosity (i) and trabecular separation (j) of the L4-L5 caudal endplates based on the μCT images. *P < 0.05 compared with the sham group and ^#P < 0.05 compared with the vehicle group at the corresponding time points. n = 6 per group. k Representative safranin O and fast green staining images of the L4-L5 caudal endplate sections at 4 weeks after the discontinuation of celecoxib or vehicle treatment. Scale bars, 50 μm